| 2022-09-03 14:00:003rd September 2022 | Reading Abb vs Cheltenham Tigers Women's XV | Away |
| 2022-09-10 14:00:0010th September 2022 | Cheltenham Tigers Women’s XV vs Bath | Newlands Park |
| 2022-09-18 14:00:0018th September 2022 | Worcester vs Cheltenham Tigers Women's XV | Away |
| 2022-10-02 14:00:002nd October 2022 | Leicester Tig vs Cheltenham Tigers Women's XV | Away |
| 2022-10-09 14:00:009th October 2022 | Cheltenham Tigers Women’s XV vs West Park Ld's | Newlands Park |
| 2022-10-23 14:00:0023rd October 2022 | Loughborough vs Cheltenham Tigers Women's XV | Away |
| 2022-11-05 14:00:005th November 2022 | Cheltenham Tigers Women’s XV vs Novocastrians | Newlands Park |
| 2022-11-13 14:00:0013th November 2022 | Harrogate vs Cheltenham Tigers Women's XV | Away |
| 2022-11-20 14:00:0020th November 2022 | Cheltenham Tigers Women’s XV vs Kenilworth | Newlands Park |
| 2022-12-03 14:00:003rd December 2022 | Barnsley (Sat) vs Cheltenham Tigers Women's XV | Away |
| 2022-12-11 14:00:0011th December 2022 | Cheltenham Tigers Women’s XV vs Bish Aukland | Newlands Park |
| 2022-12-15 14:00:0015th December 2022 | West Park Ld’s vs Cheltenham Tigers Women's XV | Away |
| 2022-12-18 14:00:0018th December 2022 | Cheltenham Tigers Women’s XV vs Leicester | Newlands Park |
| 2023-01-22 14:00:0022nd January 2023 | Cheltenham Tigers Women’s XV vs Loughborough | Newlands Park |
| 2023-01-29 14:00:0029th January 2023 | Novocastrians vs Cheltenham Tigers Women's XV | Away |
| 2023-02-12 14:00:0012th February 2023 | Cheltenham Tigers Women’s XV vs Harrogate | Newlands Park |
| 2023-02-19 14:00:0019th February 2023 | Kenilworth vs Cheltenham Tigers Women's XV | Away |
| 2023-02-25 14:00:0025th February 2023 | Cheltenham Tigers Women’s XV vs Barnsley | Newlands Park |
| 2023-03-12 14:00:0012th March 2023 | Bish Auckland vs Cheltenham Tigers Women's XV | Away |
| 2023-03-19 14:00:0019th March 2023 | Cheltenham Tigers Women’s XV vs Worcester | Newlands Park |
| 2023-04-16 14:00:0016th April 2023 | Cheltenham Tigers Women’s XV vs TBC | Newlands Park |
| 2023-04-30 14:00:0030th April 2023 | Cheltenham Tigers Women’s XV vs TBC | Newlands Park |
